Unfortunately there aren't any drugs out at the moment that boost SHBG via receptor agonism or inhibiting.
There is one drug that inhibits SHBG but that drug is under investigation and is also a birth control drug so likely not ideal for us guys!
Zinc is the only SHBG receptor modulator, its a mineral, easy to get hold of and there isn't even any drugs out currently that modulate SHBG!
Now, a receptor modulator isn't exactly a guaranteed cure for us with low SHBG, however modulators bind to receptors and regulate their activity. This can be positive, negative or neutral.
I'd like to think that a modulator would provide a boost for someone with low SHBG and anecdotally before I even started my TRT journey I do remember supplementing ZMA back in the day and having increased erections strength and frequency as well as potentially more semen volume.
Zinc is also regularly recommended as a supplement to take for increasing testosterone and I wonder if this is why.
IMPORTANT - a lot of people have mentioned about dosing Zinc and whilst I know this myself I probably should have provided some more information in that regard.
Zinc supplements are usually sold based on the amount of elemental zinc they provide. Zinc is very easy to overdose compared to vitamins for example and you should stick to no more than 30mg a day. There have been studies up to 50mg a day but they were heavily monitored with bloodwork - we cant do that.
Zinc depletes copper, if you're planning on taking it for more than a few weeks then please look into a copper/zinc ratio and add copper into your routine. Ideally just get a combined supplement.
Take zinc with a meal ideally not on an empty stomach so better not to take with breakfast.
Obviously this is not medical advice and I would hope people on this sub would do their own research from legitimate sources before ingesting anything. The majority of this sub are here because we're taking control of our own health to some extent and with that we must research.
'Positive correlation between Free Androgen Index and Zinc, Arsenic and Calcium levels. Negative correlation between SHBG and Zinc, Arsenic, Calcium and Tungsten levels.'
Our research indicates a positive relationship between the concentrations of Magnesium, Iron and Zinc and endocrine s... keep reading on reddit ➡
I've been under 399 Testosterone for the last five years (since I was 35). And in the recent year I've tested between 300-315 at 40yrs old. I was about to do trt until I discovered I have hypothyroidism and that could be causing my low Testosterone. In the meantime I decided to start taking 15mg zinc before bed every night. I noticed that the next day after taking zinc I would feel way hornier than normal. I tried to not take zinc on certain nights and saw an objective difference in libido. After taking zinc nightly for roughly a month straight I got my Testosterone checked again and I just received my highest reading in the last five years 501 ng/dL! I'm considering getting off zinc for a month and doing another test but I don't really want to experience another month of no libido. I'm not sure if anyone else has experienced this kind of result but I figured I'd share it in case anyone else struggling with their testosterone levels wanted to try as well.
I have found legitimate sources online that says it does contribute and other legitimate sources that says it doesn't.
If you suffer from horrible painful mouth ulcers, switch to a toothpaste without Sodium Laureth Sulfate (SLS) and see if they go away! A zinc supplement may also be helpful.
I’m so grateful to the random poster I learned this from, it’s saved me (and my family) so much suffering.
I started taking zinc with magnesium (before only magnesium) for better sleep and now every morning at 5 AM i wake up with a long lasting morning wood. So much about better sleep. 😁
I don't know if this post will get any attention, but I wish I could shout out loud so that everyone dealing with acne and more importantly blackheads and rough skin texture can hear it.
I was suffering with acne on the face and back for 20+ years, since my teens. I tried endless number of remedies, lotion, potions... and nothing worked, either at all, or not as much as I wanted. There were the points where I would give up, thinking that nothing can help. Two years ago I saw a Dr. Dray's video on zinc pyrithione (a common ingredient in anti-dandruff shampoos), where she explained in detail condition that many people recognise as fungal acne. She also said that it is more common on the back. Although my acne did not look like fungal, I bought a bottle of Head and Shoulders and tried it. It did not just clear my acne, but also resolved the bumpy texture of my back skin. That is when I decided to try it on the face as well. For a year now I have been using a zinc pyrithione shampoo as a face mask. I apply a thick layer on the clean skin, still damp, wait 10 mins and then rinse. Although it helps with acne (including "maskne"), it keeps me free from blackheads on the nose and the chin.
Oftentimes I see people ask how to get rid of blackheads, especially on the nose. In my case nothing has been as effective as zinc pyrithione. Using PC BHA liquid every day did a fraction of what I achieved with just an anti-dandruff shampoo. My blackheads are gone, my pores are purified and my skin is no longer bumpy under my fingers.
As zinc pyrithione shampoos are very cheap, I think it is worth trying for everyone dealing with blackheads. It's effects on dandruff and somewhat on acne is well known and usually talked about, but it may have some effects beyond these. It least speaking from my own experience.
Ejaculation is not harmful, even multiple times of it - since the nutrients lost can be recovered in a meal or two.
Because of this half truth, many people are lied to. This statement is correct, but only for macros like protein and other vitamins and minerals.
Even the shortfall in Mg and Zn can be recovered in at best a fortnight. So what is the missing key which takes such a devastating toll on our body ?
These micro nutrients are needed in amounts which would make Mg and Zn look massive. These are the real rare minerals the loss of which makes making flesh, marrow and bones from macros such a difficult task -
After knowing this, its not surprising that only the most expensive, quality checked supplements happen to have these.
I am not saying Mg and Zn are not important. All I am saying is - these micro nutrients never get the attention they deserve. And it is time they did. I strongly believe the subtle aura that every person radiates - is generated by burning these.
Just like even energy needs a material medium to travel - aura needs these along with Mg and Zn to create a significant vibrational field.
EDIT: So apparently, even after perhaps 3 mild disclaimers within the post, some cannot get this more than obvious point -
Ok so on the internet everybody seems to have a different opinion. Let's hear it from reddit.
I take magnesium for sleep and anxiety. I use magnesium bisglycinate. Take it on an empty stomach an hour or 2 before bedtime... People recommend that it's better absorbed on empty stomach. Is it true?
Also, at the same time I take zinc 25mg for testosterone and libido. Does it help for sleep? Is it okay to take it WITH the magnesium? Should I take it with food instead? Nobody knows haha
Now I take Bcomplex50 on empty stomach as soon as I wake up WITH 3000 UI of vitamin D3.
Then 45 minutes later I have breakfast... Should I take the Bcomplex with the zinc and magnesium on the evening to help with absorption? Is my plan good? Please give me feedback and maybe we can all learn something from my experience :)
Thanks in advance guys you rock!!!
Although zinc is widely prometed as a life changer mineral, it's still a heavy metal and when taken in excess; you won't pee out the unnecessary amount like the case in Vitamin C. Additionally, zinc is a fairly easy nutrition to obtain from food. Even if you are following a whole food plant based diet like me, zinc is abundant in whole grains, legumes and nuts. Adding some garlic may be enough to increase absorption rates that are decreased by phytic acid. Video: https://m.youtube.com/watch?v=ufsZ3PtMKLQ&feature=emb_title
Now, back to brain related part.
Zinc may induce excitotoxicity and increase oxidative stress when taken in excess. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356718/
High dose zinc fed rats showed signs of cognitive impairment and hippocampal zinc deficiency. (ironically)
Excess zinc cause memory problems.
For learning more about the mechanicsms that participat in zinc induced neurotoxicity.
Considering you also have intake of Zinc from foods as well, I'd never go beyond of 20mg/day supplementation to be on the safe side. Needlessly to say, eating copper rich foods are essential as well to prevent copper deficiency.
Throwing this here for prosperity and hopefully it helps someone else. In my very early forties I started experiencing loss of vigour in my erections. Within like 2 years it became impactful and a problem. I would just struggle to stay hard and it led to some awkward sexual encounters. I bought generic Viagra and took it once but I didn't like the weird feelings in my head and the racing heart etc. Also long term that shit is awful for you. I tried horny goat week which works well but came with increased aggression and a lump feeling in the throat. I decided to look I to what is lost during sex, because the more frequent sex I had the worse the problem was. I found out we mostly lose zinc and Magnesium during orgasm, so I started a supplement that contains both. Ideally I'd have also gotten one with calcium but couldn't find a triple combo.
Regardless, this has so how handedly done more for curing ED than anything else. I wake up with morning wood each morning that could pierce a steep sheet. My gf says it's the best our sex has ever been and I also feel like I have that teenage boy hardness I've not seen in over a decade. It's made all the difference and I hope this helps someone else first try a less extreme solution than Viagra.
EDIT: your mileage may vary, but I wanted to recommend this as a first option and also create a record that others may find in future. I've never seen this seemingly obvious recommendation and search on this sub for these minerals yield little results. When you ejaculate, you lose these minerals so replenishing them seemed to make sense. You also lose trace b12 and you lose calcium. Look up signs of their deficiency and make an assessment based off that.
I’m 22F, in the USA. I take prescribed Adderall 2x a day which helps me with attention and mood, but I have been trying to add supplements for overall health, especially because I have been dieting and losing a lot of weight for the last 12 months (and continuing to do so until this summer/fall when I reach a healthy weight), so I want to make sure I’m keeping up on vitamins, minerals, amino acids, etc. with my reduced calorie/food intake.
Recently had bloodwork including B12, Vit D, folate, thyroid, etc. and I don’t know any numbers, but the doctor said everything was great. However, my cognition, sleep, and general physical/mental energy levels haven’t been as great as they should be, especially for a student. Here’s what I currently am trying, including brand names and time of day taken:
Vitamin D3 50mcg (2000 IU) - NatureMade - morning
Omega 3 Fish Oil Triple Strength 2720mg (1250mg EPA) - Bronson - morning
“Neurobalance” = Zinc picolinate 24mg, magnesium citrate 752mg (120mg elemental magnesium), B6 pyridoxal-5-phosphate 20mg - igennus - half in afternoon, half in evening
l-Theanine 200mg, inositol 100mg - NOW - evening
Considering adding lion’s mane in the morning/afternoon for focus/memory and/or l-tyrosine in the evening for when Adderall wears off.
Any advice, criticisms, or recommendations are welcome, especially any tips regarding timing/absorption. I take my Adderall in the morning (btwn 8-10am?) and in the afternoon (btwn 12-2pm?) and try not to eat/drink anything with Vitamin C or citric acid for 1 hour before or after. Thanks in advance.
Edit 2: Since I don't want to give out incorrect info or recommendation, I heavily rewrote this post, and I only include the chart, without advising conversion. Some of the responses refer to the original post.
Edit: After more research, it looks like the label should list the elemental Zinc content of the supplement, so no further conversion is needed. The problem with this is that a 50 mg pill is 25% more than the advised max. of 40 mg according to examine.com. Why would manufacturers sell such a high dose? Possible explanations:
a. Examine.com is wrong about the advised max. So is the government with its Tolerable Upper Limits, 40 mg.
b. The label does not show the elemental value, but the compound one, so the elemental value is much less.
At this point I am undecided on the issue, so I will keep this post up and update it, depending on how the discussion and research goes.
In case you are interested how much elemental Zinc is in the different zinc compounds, here is the list I made using 3-4 different resources:
Type of Zinc -- Elemental Zinc in it -- Conversion ratio
Gluconate -- 14% -- 7
Ascorbate -- 15% -- 7
Picolinate -- 21% -- 4.8
Monomethionine -- 21% -- 4.8
Sulfate -- 22% -- 4.5
Bisglycinate -- 25% -- 4
Acetate -- 30% -- 3.3
Citrate -- 34% -- 3
Chloride -- 48% -- 2
Carbonate -- 52% -- 2
Oxide -- 80% -- 1.25
As for bioaviability, Orotate, Picolinate>Acetate>Gluconate>Oxide
Just like with Magnesium, Oxide is the less bioavailable form. Chelated Zinc is a type of Zinc supplement that uses a chelating agent to help your body absorb zinc more easily.
I have been feeling sluggish the past few months, and had not been able to sleep well. During this time I really started craving steak and seafood, and kind of started questioning veganism. Went to the doctor only to find out I was low with these three very important nutrients. During our talk he mentioned beans are a great source of all three. (Chickpeas being the best)
Everyday to every other day I eat roasted chickpeas as a snack or any kind of bean and I feel 100%. Most of you probably already know this, I just thought I would share for those who don’t want to take supplements!
I keep on reading that you shouldn’t take more than 40mg’s of Zinc a day. However, I’ve noticed most supplements have 50mg’s. That goes for the supplement I just bought as well. Would it be safe to take this everyday? Or maybe every other day?
Big Penny is also my rap name.
I taken magnesium glycinate and zinc bisglycinate. and I can tell you zinc 25 mg gave me the calms and lowered my heart rate. Magnesium glycinate on the other hand actually caused some anxiety. This was pretty interesting because both magnesium and zinc affect gaba level and NDMA receptor
here are the effects i had:
-bone growth (grew taller)
-absolutely destroyed acne
-so much less anxiety
-more confidence (like this boost)
If calcium, magnesium and zinc all compete for absorption, why do companies sell supplements that combine these exact three?
So my results showed a zinc deficiency with low copper levels, i suspected i had a zinc deficiency so i was supplementing with 30mg zinc glycinate before i got tested, although i was surprised by my copper levels which explained some of my symptoms. From what i understand supplementing with zinc alone would further decrease my copper levels, can you guys recommend a good supplement in this case? I'd like to have both mineral levels at the higher end. Much appreciated!
For those interested
I'm also vitamin d deficient so I'm taking 50000iu per week
The only changes I made was introducing Potassium and reintroducing Zinc at a higher dosage. The first day I used the Zinc again it caused euphoria for almost the entire day. The Potassium made my heartrate go down significantly over a few days, got rid of any extra-beats and was a blessing overall, it's just that now I oftentimes feel my heartbeat in my torso and it makes me seriously uneasy. I'm a guy with anxiety btw, just to mention it. I'd appreciate all pointers and ideas, cheers guys
I’ve struggled with SD for over 7 years now, but during the last 3 I’ve had it more or less under control (roughly one flare-up per month, lasts 3-4 days).
In fact, I committed myself this year to actually keeping TRACK of every time I had a flare-up, and the duration of it. I consistently use the DermaHarmony 2% Zinc Pyrithione soap bar, and Since January, the longest flare-up I had lasted 5 days.
However, I came back to my parents house for the holidays, and forgot my soap bar at home. Following that, I had a flare-up that got worse and worse, and ended up lasting TEN days. From my experience this year, I knew this was very much abnormal!
I ordered a new bar on Amazon immediately, and used it on my face. Over the next few days, I could literally feel the flakes just falling off of my skin when I applied the zinc soap, it was like a miracle.
I don’t know if this was coincidence, but all this to say, I have been having a lot of success with the DermaHarmony Zinc Therapy soap BAR!! (But PLEASE moisturize after, it can be very drying)
Hope this helps someone
Basically what the title says. I am a 20 year old college student, and so far my entire skincare routine has involved biotique bio honey gel facewash once or twice a day, and aloe vera gel and vaseline cherry lip balm. I use clindamycin nicotinamide gel for the couple of hormonal acne that pop up right before my period.
I have combination skin, and I've recently gotten into skincare. I have a lot of old acne scarring between my brows, from back when i was a teen and had really bad breakouts. I was thinking of trying out some niacinamide actives to fix those, or at least make them less obvious.
What would you recommend? Should i take some time to get used to the 5% niacinamide, or can i dive right into the 10%?
Also, any suggestions for products that could constitute an affordable and effective skincare routine for a brokeass college student would be veeeeeery welcome.
Thanks in advance!
I was taking Zinc and Vitamin D prior to Covid. Both are necessary for testosterone production, and as you’ve seen with the pandemic, there’s a lot of Vitamin D deficiency out there.
I’ve been able to find Vitamin D fairly easily, but Zinc has been more difficult. DG usually has it. Got 3 bottles this am.
Hi guys has anyone used this product before sorry if it’s a dumb question I just have never put anything on my face for sebderm has anyone had any success with this product or any problems? And are the ingredients good for sebderm? 2% zinc soap
Hi, Im looking for a sunscreen with the following qualities:
If you guys have any recommendations, let me know! Thanks
Zinc has been shown to increase sperm quality and production. Many of us usually consume enough zinc because it's found in meat, but for the vegetarians/vegans out there, I recommend taking zinc supplements or hard candy. I've always wondered why I experience positive effects of semen retention on day 3 or 4 on semen retention unlike the people that say they experience it after 10 days or a month, but then I remembered that I eat two zinc hard candies a day. No I'm not vegan or vegetarian, but you guys should really try it. It helps tremendously.
Edit: I did further research to provide further help. Zinc also blocks the enzyme that turns testosterone to estrogen. Estrogen is essential for bone health but in this day and age, estrogen levels are WAY too easy to increase, making it something that you shouldn't have to be worried about increasing on purpose. So if you consume enough zinc daily, while on semen retention. Your body will be making little to none estrogen which will make you into the masculine man you want to become especially if you work out. Zinc also rapidly increases testosterone to a healthy amount, so you'll see a significance in muscle gain and over all masculinity. However, zinc does increase sex drive which can make your semen retention journey harder, but if you can get past your increased urges, you'll seriously become the man you want to be ridiculously fast if you combine enough zinc, semen retention, working out (heavy lifting and sprinting increase testosterone more than any other workout), if you decrease or erase your sugar intake (because consuming sugar increases estrogen), and if you meditate to lower cortisol which kills testosterone. I can't even describe how fast your transformation will be.
Edit #2: Keep in mind that training your leg muscles create the most testosterone out of all the muscle groups in your body. DON'T SKIP LEG DAY
Never expected supplements/herbs to help this much. But Ive been taking them for around 1 month and its really calming. Like il still get anxiety but its not those uncontrollable heart palpitations that I had. Fyi my heart rate used to be at 105-115, now its at 75 with anxiety (I suffer from cardiophobia, so this is really great for me). Its great. Thankfully I didnt choose the SSRI route because it causes permanent damage like r/PSSD
Some studies on L-Theanine:
whats the best form
I can't live like this. I am 24 years old. Everything I eat is cardboard and all I smell is is this weird bleach smell occasionally which give me the worst headache. I have lost my job and I am running out of money as well.
Offing myself looks like the best option for me. This virus has ruined me. You win COVID. You win.
I have tried so many things for POIS and its symptoms, including antihistamines, Quercetin, vitamin D, niacin, all of which didn't do much.
In my journey of trying various supplements, I decided to give Zinc Picolinate a go (40mg daily) and my symptoms have improved: my eczema is feeling better, I am feeling less fatigued and my IBS symptoms aren't so bad.
Could this be either a Zinc deficiency or could it be having an effect on testosterone (given there have been suggestions that POIS can be linked to hormones)? I am not sure about testosterone as I had a test a few months ago which indicated I had normal levels, albeit my prolactin was slightly high (but still within the normal range).