Nanoscale chains from a simple monomer held together only by noncovalent interactions. Making such a complex supramolecular structure from such a simple building block takes self-assembly to a new level. (source: Yagai et. al. in Nature, 2020 via cen.acs.org)
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📅︎ Dec 22 2020
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Literature recommendations: nanoscale photochemistry, biological interaction with silicon substrates, discussion, ideas?

I'm a programmer with a interest in bioengineering and bioinformatics, and a background in computer engineering.

As I learn more about the way integrated circuits are constructed, and the way they operate, and the way that biochemistry is conducted within cells, I'm starting to see a few parallels in the way that charges are transferred, and the role played by electromagnetism. The scales are pretty close: Intel now produces excellent transistors as small as 7nm, while proteins seem to be about that large in diameter. And while the mechanics couldn't be more different if you tried (if your transistor ions are flowing, you're not going to have a transistor in the very near future), maybe we're at a point where a discussion about some of this stuff can be had rooted in science and real ongoing research, instead of science fiction.

By the way, I bolded specific questions I have for ease of reading.

To be clear, I have no idea what I'm doing. I have zero background in nanofabrication, and primarily deal with software. I've barely even read any literature on the topic (gathering a reading list is half of why I posted this thread) But my hope is that I can attract some people who have that background, and learn something from the discussion.

That said, I'll try to gather a few resources that helped me better picture the options nanotechnology would have for interacting with chemical reactions. I can't really do the same for biochemistry, since I don't have a foundation in chemistry to draw on like I do with electrical engineering. getting a picture of the enzymes, chemistries, and interactions of interest is another reason for this post.

  1. A working and well-established example of combining integrated circuits and nanoscale chemistry would probably be the ISFET device. It seems to have quite a few variants and derivatives. It seems even commercial applications are being deployed now. At its core, it is a FET switch, a form of transistor which relies on the electrostatic field exerted by a "gate" electrode to promote or discourage the formation of a conductive channel in a layer of silicon separated from the gate by a layer of insulation. by modifying the surface charge using functional groups bonded to this insulation the transistor can be made to switch. This is a Bio-FET. **Any papers on how these ar
... keep reading on reddit ➡

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📰︎ r/biology
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📅︎ Jan 16
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NASA scientists design a nanoscale complementary vacuum field emission transistor physicsworld.com/a/nasa-s…
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📅︎ Dec 27 2020
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Literature recommendations: nanoscale photochemistry, biological interaction with silicon substrates, discussion, ideas? /r/biology/comments/kys17…
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📅︎ Jan 16
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Energy Efficient Ultrahigh Flux Separation of Oily Pollutants from Water with Superhydrophilic Nanoscale Metal–Organic Framework Architectures

In this work we introduce the synthesis of a pillar‐like Co‐CAT‐1 MOF nanoarchitecture on gold‐coated woven stainless steel meshes. These nanostructured mesh surfaces feature extreme superhydrophilic and underwater superoleophobic wetting properties, allowing for gravity‐driven, highly efficient oil–water separation with ultra‐high flux of up to nearly one million L m−2 h−1.

Abstract

The rising demand for clean water for a growing and increasingly urban global population is one of the most urgent issues of our time. Here, we introduce the synthesis of a unique nanoscale architecture of pillar‐like Co‐CAT‐1 metal–organic framework (MOF) crystallites on gold‐coated woven stainless steel meshes with large, 50 μm apertures. These nanostructured mesh surfaces feature superhydrophilic and underwater superoleophobic wetting properties, allowing for gravity‐driven, highly efficient oil–water separation featuring water fluxes of up to nearly one million L m−2 h−1. Water physisorption experiments reveal the hydrophilic nature of Co‐CAT‐1 with a total water vapor uptake at room temperature of 470 cm3 g−1. Semiempirical molecular orbital calculations shed light on water affinity of the inner and outer pore surfaces. The MOF‐based membranes enable high separation efficiencies for a number of liquids tested, including the notorious water pollutant, crude oil, affording chemical oxygen demand (COD) concentrations below 25 mg L−1 of the effluent. Our results demonstrate the great impact of suitable nanoscale surface architectures as a means of encoding on‐surface extreme wetting properties, yielding energy‐efficient water‐selective large‐aperture membranes.

https://ift.tt/2SxdYLi

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📅︎ Jan 18
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Ion beams are super fun and insanely versatile - not only can it punch holes in cells to photograph them, but it's basically a combination 3D printer, welder, and programmable cutter that works at the nanoscale. (Super fun to play with after hours!) This entire field of view is smaller than a hair. gfycat.com/difficultelate…
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📅︎ Dec 15 2020
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EPFL biophysicists have developed a high-throughput super-resolution microscope to probe nanoscale structures and dynamics of mammalian cells, showing in unprecedented detail the twists and turns of an organelle important for cell division. v.redd.it/w79qkltkulc61
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📰︎ r/Wevolver
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📅︎ Jan 21
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Literature recommendations: nanoscale photochemistry, biological interaction with silicon substrates, discussion, ideas? /r/biology/comments/kys17…
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📅︎ Jan 16
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Literature recommendations: nanoscale photochemistry, biological interaction with silicon substrates, discussion, ideas? /r/biology/comments/kys17…
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📅︎ Jan 16
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Literature recommendations: nanoscale photochemistry, biological interaction with silicon substrates, discussion, ideas? /r/biology/comments/kys17…
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📅︎ Jan 16
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If the imprints of the ink were thick enough theoretically we could all feel 2D boobs. (Human fingers can detect wrinkles on a nanoscale level. Source: KTH The Royal Institute of Technology, 2013)
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👤︎ u/Nomad_9811
📅︎ Sep 03 2020
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Nanoscale Hyperspectral Imaging of Amyloid Secondary Structures in Liquid

Tip‐enhanced Raman spectroscopic (TERS) mapping in liquid is shown to be an efficient tool to investigate the secondary structure of the neurodegenerative peptide amyloid‐β. The high heat capacity of liquid increased the capability of TERS, allowing an observation of the conformational transition from the antiparallel arrangement of β‐sheets in protofibrils to parallel in fibrils, at the single aggregates level.

Abstract

Abnormal aggregation of amyloid‐β is a very complex and heterogeneous process. Owing to methodological limitations, the aggregation pathway is still not fully understood. Herein a new approach is presented in which the secondary structure of single amyloid‐β aggregates is investigated with tip‐enhanced Raman spectroscopy (TERS) in a liquid environment. Clearly resolved TERS signatures of the amide I and amide III bands enabled a detailed analysis of the molecular structure of single aggregates at each phase of the primary aggregation of amyloid‐β and also of small species on the surface of fibrils attributed to secondary nucleation. Notably, a β‐sheet rearrangement from antiparallel in protofibrils to parallel in fibrils is observed. This study allows better understanding of Alzheimer's disease etiology and the methodology can be applied in studies of other neurodegenerative disorders.

https://ift.tt/3mJQeSj

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📅︎ Jan 08
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Nanoscale Model of New York
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👤︎ u/Axcit
📅︎ Jul 23 2020
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In Vivo Uranium Sequestration using a Nanoscale Metal–Organic Framework

A carboxyl‐functionalized UiO‐66 nanoparticle (UiO‐66‐(COOH)4‐180) is first used as an uranyl sequestration agent, which exhibits ultrafast and selective adsorption of uranyl and could successfully reduce the amounts of uranyl deposited in kidneys and femurs by up to 55.4 % and 36.5 %, respectively.

Abstract

An agent for actinide sequestration with fast uranium uptake kinetics and efficient in vivo uranium removal using a nanoscale metal–organic framework (nano‐MOF) is proposed. UiO‐66 nanoparticles post‐synthetically functionalized with carboxyl groups, UiO‐66‐(COOH)4‐180, exhibit the fastest uranium uptake kinetics reported with more than 65 % of uranyl in fetal bovine serum (FBS) removed within 5 min. Moreover, the in vivo bio‐distribution studies show that the material partially accumulates in kidneys and femurs where uranium mainly deposits facilitating the in vivo sequestration of uranium. The results of the in vivo uranium decorporation assays with mice show that UiO‐66‐(COOH)4‐180 could successfully reduce the amounts of uranyl deposited in kidneys and femurs by up to 55.4 % and 36.5 %, respectively, and is significantly more efficient than the commercial actinide decorporation agent, ZnNa3‐DTPA.

https://ift.tt/3lt4AEW

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📅︎ Jan 12
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[ASAP] Nanoscale Metal–Organic Layers Detect Mitochondrial Dysregulation and Chemoresistance via Ratiometric Sensing of Glutathione and pH

Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c11764

Xiang Ling, Deyan Gong, Wenjie Shi, Ziwan Xu, Wenbo Han, Guangxu Lan, Youyou Li, Wenwu Qin, and Wenbin Lin

https://ift.tt/35K18jT

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📅︎ Jan 15
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Liquid Nanoparticles: Manipulating the Nucleation and Growth of Nanoscale Droplets

Manipulation of liquid droplet like nanoparticles: To mimic the classic synthetic methods of nanoparticles, a bottom‐up approach for the fabrication of nanoscale droplets has been developed. Synthetic techniques for solid nanoparticles, such as burst nucleation, seeded growth and co‐precipitation, have been transferred to liquid droplets. This leads to the facile fabrication of multishell hollow structures, nanoreactors and carriers.

Abstract

By manipulating the nucleation and growth of solid materials, the synthesis of various sophisticated nanostructures has been achieved. Similar methodology, if applied to liquids, could enable the mass‐production and control of ultra‐small droplets at the scale of nanoparticles (10−18 L or below). It would be highly desirable since droplets play a fundamental role in numerous applications. Here we present a general strategy to synthesize and manipulate nanoscale droplets, similar to what has been done to solid nanoparticles in classic solution‐synthesis. It was achieved by a solute‐induced phase separation which initiates the nucleation of droplets from a homogeneous solution. These liquid nanoparticles have great potentials to be manipulated like their solid counterparts, borrowing from the vast methodologies of nanoparticle synthesis, such as burst nucleation, seeded growth, and co‐precipitation. Liquid nanoparticles also serve as a general synthetic platform, to fabricate nanoreactors, drug‐loaded carriers, and other hollow nanostructures with a variety of shell materials.

https://ift.tt/2H6IzgX

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📅︎ Jan 07
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Researchers apply nanoscale graphene 'magic' angle to acoustics news.psu.edu/story/639261…
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📰︎ r/graphene
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📅︎ Dec 07 2020
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Controlling the nanoscale structure of membranes is key for clean water, researchers find phys.org/news/2020-12-nan…
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👤︎ u/rwoooshed
📅︎ Jan 02
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Nanoscale Warming Is Faster Than Cooling physics.aps.org/articles/…
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📅︎ Oct 08 2020
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A new optical matter machine can perform mechanical work when illuminated by polarized light. The self-assembling, nanoscale device functions as a gear, rotating in response to polarized light. Because it operates in solution, it has applications in nanofluidics and particle sorting. osapublishing.org/optica/…
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📅︎ Nov 08 2020
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The Mini Lisa is a nanoscale replica of the Mona Lisa. It was created in 2013 by Keith Carroll, a PhD candidate, in order to demonstrate a technique called thermochemical nanolithography. The Mini Lisa is just 30 micrometres (0.0012 in) wide, about a third the width of a human hair. en.wikipedia.org/wiki/Min…
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📅︎ Nov 24 2020
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Nanoscale amperometry reveals only a fraction of vesicular serotonin content is released during exocytosis from beta cells

Recent work has shown that chemical release during the fundamental cellular process of exocytosis in model cell lines is not all or none. We tested this theory for vesicular release from single pancreatic beta cells. The vesicles in these cells release insulin, but also serotonin, which is detectible with amperometric methods. Traditionally, it is assumed that exocytosis in beta cells is all‐or‐none. Here we use a multidisciplinary approach involving nanoscale amperometric chemical methods to explore the chemical nature of insulin exocytosis. We amperometrically quantified the number of serotonin molecules stored inside of individual nanoscale vesicles (39317 ± 1611) in the cell cytoplasm before exocytosis and the number of serotonin molecules released from single cells (13310 ± 1127) for each stimulated exocytosis event. Thus, beta cells release only one‐third of their granule content, clearly supporting partial release in this system. We discuss these observations in the context of type‐2 diabetes.

https://ift.tt/3mxVuqL

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📅︎ Dec 19 2020
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More Nanoscale Alliance Fighters
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👤︎ u/coolgr3g
📅︎ Oct 17 2020
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A light bright and tiny: NIST scientists build a better nanoscale LED sciencecodex.com/light-br…
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📰︎ r/tech
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👤︎ u/Sorin61
📅︎ Aug 16 2020
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University of Chicago researchers have developed a tiny new machine that converts laser light into work. These optically powered machines self-assemble and could be used for nanoscale manipulation of tiny cargo for applications such as nanofluidics and particle sorting. scitechdaily.com/optical-…
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📰︎ r/Futurology
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👤︎ u/lughnasadh
📅︎ Oct 25 2020
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The Aliens Exist—But Evolved Into Virtual Reality at a Nanoscale mindmatters.ai/2020/11/th…
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💬︎
📅︎ Nov 15 2020
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[R] Breakthrough Neuron-Mimicking Nanoscale Electronic Circuit Element for Neuromorphic AI

In a paper recently published in Nature, researchers Suhas Kumar of Hewlett Packard Laboratories, R. Stanley Williams with Texas A&M University, and the late Stanford PhD student Ziwen Wang introduce an isolated nanoscale electronic circuit element that can perform nonmonotonic operations and transistorless all-analogue computations. With input voltages, it can output not just simple spikes but a whole array of neural activity such as bursts of spikes, self-sustained oscillations, and other brain activities.

Here is a quick read: Breakthrough Neuron-Mimicking Nanoscale Electronic Circuit Element for Neuromorphic AI

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👤︎ u/Yuqing7
📅︎ Oct 07 2020
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What are nanoscale materials?

I'm looking at grad schools for condensed matter and just stumbled into this research area. I would like to hear a bit about it. Any responses are very much appreciated!

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📰︎ r/AskPhysics
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👤︎ u/Task876
📅︎ Nov 06 2020
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In situ Nanoscale Infrared Spectroscopy of Water Adsorption on Nanoislands of Surface‐Anchored Metal‐Organic Frameworks

A new in situ nano‐spectroscopy technique elucidating the guest–host chemistry between Metal‐Organic Frameworks (MOFs) and water vapor is described. By using adapted Photoinduced Force Microscopy (PiFM) on amphiphilic surfaces of mixed HKUST‐1/ZIF‐8 films, site‐specific D2O gas sorption isotherms could be determined. Furthermore, using in situ PiFM, the real‐time evolution of defective HKUST‐1 paddlewheels on the surface could be visualized.

Abstract

Despite technological advancements, probing gas‐solid interfaces at the nanoscale is still a formidable challenge. New nano‐spectroscopic methods are needed to understand the guest–host interactions of functional materials during gas sorption, separation, and conversion. Herein, we introduce in situ Photoinduced Force Microscopy (PiFM) to evidence site‐specific interaction between Metal‐Organic Frameworks (MOFs) and water. To this end, we developed amphiphilic Surface‐anchored MOF (SURMOF) model systems using self‐assembly for the side‐by‐side hetero‐growth of nanodomains of hydrophilic HKUST‐1 and hydrophobic ZIF‐8. PiFM was used to probe local uptake kinetics and to show D2O sorption isotherms on (defective) HKUST‐1 paddlewheels. By monitoring defect vibrations, we visualized in real‐time the saturation of existing defects and the creation of D2O‐induced defects. This work shows the potential of in situ PiFM to unravel gas sorption mechanisms and map active sites on functional (MOF) materials.

https://ift.tt/30sC4vq

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📰︎ r/ACIE
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📅︎ Nov 23 2020
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[R] Breakthrough Neuron-Mimicking Nanoscale Electronic Circuit Element for Neuromorphic AI

In a paper recently published in Nature, researchers Suhas Kumar of Hewlett Packard Laboratories, R. Stanley Williams with Texas A&M University, and the late Stanford PhD student Ziwen Wang introduce an isolated nanoscale electronic circuit element that can perform nonmonotonic operations and transistorless all-analogue computations. With input voltages, it can output not just simple spikes but a whole array of neural activity such as bursts of spikes, self-sustained oscillations, and other brain activities.

Here is a quick read: Breakthrough Neuron-Mimicking Nanoscale Electronic Circuit Element for Neuromorphic AI

👍︎ 82
📰︎ r/compsci
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👤︎ u/Yuqing7
📅︎ Oct 07 2020
🚨︎ report

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