Found this out when googling why my meds took 2 hours to hit (it's usually 20 mins). I had half a lime in some guac in my breakfast and as confirmed by my psych this does indeed affect the absorption of our meds. Not only does it slow it down, but the acid can actually break down the meds before they're absorbed - meaning they're lost, that's it. Jeez.
For anyone who has issues with this, try to avoid orange juice and fruits that contain a lot of citrus. Even if you have fruits like pineapple, strawberries, raspberries, cranberries, cherries or tomatoes, these have small amounts of citrus in them and could be a factor in your rate of absorption! Lots of processed foods contain citric acid too (such as chips), so check labels too.
Citric foods should be safe to consume around one hour after taking meds, but of course check this with your doctor.
So I didn't think that I was battling with active weed addiction anymore since at least late 2019 (when daily smoking was still a thing for me and had been for the previous 7 or so years). I dramatically cut back and for pretty long periods completely abstained, mostly due to the fights and arguments I would have with my girlfriend (bless her kind and caring soul). I distinctly remember the immense clarity I regained after stopping constant abuse of weed.
That being said, along with the belief that I was past my addiction to weed, I had continued to hold onto the belief that occasional recreational use was still a possibility. I further justified this for myself by thinking I'd restrict my intake to healthier forms of ingestion, like vaping or edibles.
In the beginning of lockdown last year, I acquired a pretty tremendous amount of homegrown from friends. Since I was already on a journey of quitting vaping nicotine at that time, plus the unfolding of a respiratory disease pandemic before my eyes, I decided smoking was not going to be a good way for me to consume weed. Remember being a weed addict was "something of the past" to me at this point. Instead, I resorted to the occasional vape, but mostly went with using edibles. During lockdown I made some infused coconut oil, and enjoyed it on weekends. At first my use was pretty sparse, but it definitely did escalate over time, moreso in dosage than frequency, to the point that I'd be taking doses that made me feel super uncomfortable around my girlfriend and family even. I further justified this to myself because of the novel event of being in lockdown and the anxiety and boredom it brought forth (ha! how naive). I eventually ran out of the coconut oil and never got to making any more, and up until a week or two ago I was still planning to make some more when I had some free time.
It's been a long process of learning and realisation, but it truly hit me today and I realised the right thing for me to do was completely bin the stuff, and detach myself from the idea that having edibles occasionally "in a recreational" sense was even viable or a good idea. I felt amazing doing it, albeit slightly anxious (which is so telling!).
This drug has actually caused me a great amount of harm in my life in terms of my emotional functioning and regulation over time, it's pretty shocking to admit. Sure there were some really fun and great times with it, especially in the early days, but I wouldn't wish the negative mar... keep reading on reddit ➡
Impair cognitive abilities - It's harder to learn new things or remember things. Your coordination and reflexes are slower than before. Reading and writing take a lot longer to do(i.e taking 5 minutes to read 2 paragraphs). And you slur in your speech and are unable to make witty or quick banter anymore.
I (24 M) am currently leasing a house with two friends (23 F, 22 M) who are a couple. I will be leaving in a few months, and the company we are leasing from only leases to complete groups (two bedrooms) and requires substitutions to be handled by the tenants. Meaning that if my friends can't find a replacement for me OR I refuse to sign off on the replacement, they will be kicked from the house while the company inspects the property, refunds deposits, likely raises rent, and searches for a group of three.
I have no problems with signing for a replacement, and the deadline to find a replacement is quickly approaching. As my friends have been searching for replacements, they have invited the replacements to come tour the house, including my room, with no or little prior notification to me. Recently, they invited a replacement to tour the house while I was working virtually, and only informed me an hour before the replacement arrived. Afterwards, I asked them to check with me that I am fine with them inviting someone to tour the house before they invite them, because I may be busy while they are trying to advertise my room. When they refused, I threatened them with not signing for the replacement.
Important context is that they are pressed for time and the lack of time is partially my fault, because we only started talking about if we were staying a month before the deadline, and I only told them I was leaving for sure two weeks before the deadline. Another potentially important piece of context is that they previously asked if I minded if they bought a pet for the apartment, and while I said I didn't mind, I later found out they had already purchased and brought the pet home before asking me.
Who here is the AH?
I probably have UARS, because I'm young, thin and chronically half asleep. Tomorrow I'll finally have my sleep study.
I was wondering the following: Does UARS impair the brain in a similar way as regular OSA? I've noticed a decrease in cognitive functioning and am hoping this is reversible.
After reading about how casual sex ruins women's ability to pair-bond because of oxytocin, I decided to look at reputable sources to see if there's any evidence of this. I didn't find anything to support this claim. However, I found some interesting information that I thought should be brought up here for discussion.
Turns out that oxytocin also increases during:
At this point you might be asking how is this relevant? It's relevant because if casual sex reduces a woman's ability to pair-bond, how come that nobody claims that oxytocin release from visiting many massage parlors, overeating or traveling to the tropics also hurts pair-bonding in women (or in men, for that matter)?
Furthermore, if sex releases oxytocin the same way stimulants release dopamine, why the belief that a woman who slept with 20 different men 20 times has more difficulties pair-bonding than a woman who's slept with one man 1000 times? At the end of the day, the later has triggered her oxytocin release many more times than the former. And yet, I'd become a laughing stock if I said that hitting the pipe every day wouldn't get me addicted as long as I bought meth from the same supplier.
Researchs says (S)SNRI impair LTP in rat hippocampus. LTP is important mechanism for long-term learning and memory. What do you think? Thanks.
Especially if you’re bragging about it, you piss me off. You should be as attentive as possible when driving. We don’t need any more disastrous traffic accidents. It’s not fair for you to hurt someone else. Be respectful. Driving is dangerous enough already without you endangering everyone around you. Do your drugs responsibly. That is all.
[email protected] is restricting the account's privileges and abilities without making it visible for the user.
This would drastically decrease the efficiency of bots as there would be a lot more wasted processing power & effort put into accounts which have gone sour long ago.
The methods & theories can be improved but in general the idea should at the very least drastically limit the capabilities of what beginner botters can do.
Hav... keep reading on reddit ➡
Some clinical trials are investigating modafinil (Mod) as a treatment for attentional deficit and hyperactivity disorder (ADHD) in children and adolescents. Mod increases dopamine (DA) levels in the reward system by blocking dopamine transporter (DAT). Social interactions are rewarding behaviors and evidence reveals the importance of reward circuitry in social interactions. Chronic psychostimulant treatments alter DA neurotransmission and associated behaviors.
The aim of this work was to evaluate the effects of chronic Mod treatment during preadolescence on social play behavior, locomotor activity, and DA in nucleus accumbens (NAc). Preadolescent male Sprague-Dawley rats were injected with Mod (75 mg/kg i.p.) or vehicle for 14 days (PND22 to PND35).
After that, we measured social play behavior, content and DA release in NAc by HPLC coupled to electrochemical detection, protein levels of DA type 2 receptor (D2) by Western blot and DA kinetic by fast-scan cyclic voltammetry (FSCV) in NAc.
Regarding social play, the total number of pinning events decreased in the Mod group compared with the vehicle. The K+-stimulated DA release in NAc was significantly lower in Mod-treated rats compared with vehicle group. Also, Mod increases locomotor activity at the first injection, but this effect is almost completely lost at day 14 of Mod treatment.
Chronic Mod treatment during preadolescence in rats impairs dopaminergic neurotransmission in NAc and decreases the capacity of rats to perceive rewarding effects of social play. Importantly, as Mod is being evaluated to treat ADHD in children and adolescents, potential effects on social behavior should be considered since this kind of behavior in this particular stage is crucial for neurodevelopment.
Would such impairing thoughts be considered risk factors for mental illness?
What are some ways to reduce or alleviate this line of thinking and associated behaviors and emotions resulting from those thoughts?
I understand that marijuana and etc can stay in your system a long time and you can get pinged on a road side drug test a long time after the effects have worn off. Do you think that they're going to change the law to accommodate these findings or do you think that legal and illegal users alike are going to be unable to drive if they consume marijuana and etc?
News: Cannabis component CBD doesn't impair driving skills, Australian study finds. https://www.9news.com.au/national/medical-cannabis-research-finds-not-as-bad-for-driving-as-thought/29151058-6b62-45ba-90e4-c294bbb05512
Sports Medicine doctor says to wear firm, padded shoes during my injury recovery (Hoka and Brooks Beast/Ariel specifically—opted for Hoka Gaviota 2).
At the same time, a running coach/physiotherapist I’m seeing recommends a more minimalist shoe to help encourage natural movement and muscle balance.
I’m not asking for medical advice here, but is there more to shoes than just “what feels good?” They both have good points—is there a benefit to rotating between shoe types altogether? And, are my plush, cushioned shoes hurting form in the long run? All Google research points in a million different directions, and as someone who is relatively new to running, I never know what sources to trust.
I have an obsession with shoes, so I don’t mind spending the money, but it’s even more confusing when I visit my local running shop and get their opinion thrown in the mix. I don’t want my shoes lying to me.