Hypercalcemia

i had supplementing only with vitamin D and it was getting me Hypercalcemia symptoms. blural vision, iritability, anxiety, joint and muscle pain, trouble thinking(as like light headed)

when i stopped taking vitamin D after one a month, symptoms little reduced, but i have trouble thinking(foggy mind) , strong anxiety... i checked ionized calcium, but there is balance. can high calcium challenged some a issue?

https://preview.redd.it/ki9iwey4zjh61.png?width=815&format=png&auto=webp&s=12e11a6013a1f57153c2c2a5c898eb693a4a6398

My two most recent CMP blood tests came back with elevated calcium levels (not severely hypercalemic just right on the line of mild hyper 10.2) and I don’t know why. I don’t have a parathyroid issue. My potassium and sodium levels were not elevated but still normal.

After these tests were done, I started experiencing constant muscle twitches and thought maybe I had a magnesium deficiency but after 2 weeks of magnesium I still can’t get rid of the full body muscle twitches all the time. I do take around 70mg total of calcium a day from electrolyte powder (helps with POTS symptoms) and a supplement I take contains calcium as a cofactor. I do either 1000-2000 IU a day or vitamin D3/k2. I do experience joint pain but I assumed it was from my other health issues. I drink almost 60 oz of water a day (plus the electrolyte powder) so I’m hydrated. My health anxiety is making me stressed about this. Should I be cautious about my calcium intake, or am I stressing for no reason? If it weren’t for the muscle twitches and joint pain I probably wouldn’t be concerned about it.

So it’s been a really interesting year or so. Found out a few months ago that I have this pretty massive tumor in one of my parathyroids, which I’m having surgery for in 10 days. Along with this comes some really fun hypercalcemia (this is where my body takes the calcium from my bones and throws all of it into my blood stream, causing havoc on just about every part of my body, also causes osteoporosis) And I also have next to no vitamin D but I can’t even do anything about that until the tumor gets removed.

And then I found out that I also have Hashimoto’s, which I seem to have inherited from my mom, who also has it. So there’s been a huge Aha! moment as it all comes together and explains why I’ve felt so incredibly dreadful for the last few years, with the last year being completely horrific, frustrating and at times almost unbearable.

The plan is to address the parathyroid issue with surgery first, which will take care of the hypercalcemia and I can then address the vitamin D issue. And after that, try to get the thyroid sorted. But I’m just trying to get as much information about Hashimoto’s now, I already understand the rest of what’s going on with me quite well, but if anyone has any resources or links to some good information, that’d be awesome and extremely appreciated.

I also was curious if anyone else has gone through this with the hyperparathyroidism with Hashimoto’s at the same time, too. Thank you very much in advance!

31m 5’9” 189

My last 2 blood tests came back with my calcium level at 10.6 and my albumin level at 5.4.

I’m wondering how serious this is? Google is telling me I have cancer and I’m going to die.

Can someone please give me some clarity on this? I had my PTH and that was at 22 pg/ml

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Is 10.3 considered hypercalcemia for a 27 year old i read upto 10.5 is considered normal however reference range differs on each site!

Hawkes CP, Roy SM, Dekelbab B, Frazier B, Grover M, Haidet J, Listman J, Madsen S, Roan M, Rodd C, Sopher A, Tebben P, Levine MA. Hypercalcemia in Children Using the Ketogenic Diet: A Multicenter Study. J Clin Endocrinol Metab. 2020 Oct 30:dgaa759. doi: 10.1210/clinem/dgaa759. Epub ahead of print. PMID: 33124662.

https://doi.org/10.1210/clinem/dgaa759

https://pubmed.ncbi.nlm.nih.gov/33124662/

Abstract

Context: The ketogenic diet is associated with progressive skeletal demineralization, hypercalciuria and nephrolithiasis. Acute hypercalcemia has been described as a newly recognized complication of this treatment.

Objective: To describe the clinical characteristics of acute hypercalcemia in children on the ketogenic diet through analysis of the presentation, response to treatment, and natural history in a large cohort of patients.

Design: A multicenter case series was performed including children who developed acute hypercalcemia while treated with the ketogenic diet. Information on clinical presentation, treatment and course of this complication was collated centrally.

Results: There were 14 patients (median (range) age 6.3 (0.9 to 18) years) who developed hypercalcemia 2.1 (range 0.2 to 12) years after starting the ketogenic diet. All had low levels of parathyroid hormone and levels of 1,25-dihydroxyvitamin D were low in all except one. Seven (50%) had impaired renal function at presentation. All except the two oldest had low alkaline phosphatase levels for age. Once normocalcemia was achieved, hypercalcemia recurred in only two of these patients over observation of up to 9.8 years. One patient discontinued the ketogenic diet prior to achieving normocalcemia while four more stopped the diet during follow-up after resolution of hypercalcemia.

Conclusions: Ketotic hypercalcemia can occur years after starting the ketogenic diet, especially in the setting of renal impairment. The mechanism is unknown, but appears to be due to reduced osteoblast activity and impaired bone formation. We recommend close attention to optimizing bone health in these children, and screening for the development of ketotic hypercalcemia.

24F Medications: birth control pill, miralax and omeprazole every day Non-smoking

For context, I’ve had some ongoing muscle pains and weakness the past couple of months (along with muscle tingling and twitching) that hasn’t been diagnosed as anything at this point.

The past three blood tests my doctor ran, she found my calcium levels to be at 10.4. She checked my parathyroid levels, and those were normal. What other reasons would one’s calcium levels be high? When researching online, the only explanations I see are parathyroid tumors or various forms of cancer.

I’ve also been feeling very shaky and dizzy recently, and I want to make sure this couldn’t be related to the high calcium. My doctor isn’t running any further tests to detect the issue, should I be asking for more tests?

31 | Male | 6'1" | 258lbs | White |6 Months | Canada

Currently taking 120mg of Diltiazem daily for high blood pressure (possibly due to anxiety)

I'm in the midst of investigating hypercalcemia (had a parathyroid scan this week which showed no growths) and I just have a question based on something my doctor said about determining if I have 'true hypercalcemia'.

I've read that sometimes albumin levels can artificially inflate total calcium levels, just wondering how true that is? My doctor hasn't mentioned it to me but still ordered the parathyroid scan after seeing my bloods. (I'm 100% on board with whatever my doctor recommends, to be clear, just for my own peace of mind). My numbers from my most recent blood labs are below:

Calcium : 2.60 mmol/L - Normal Range 2.15–2.60

Calcium Ionized : 1.35 mmol/L - Normal Range 1.15 - 1.4

PH : 7.38

Albumin : 48 g/l - Normal Range 35 - 52

PTH Intact - 6.4 pmol/L - Normal Range 1.6 - 6.9

Vitamin D was also low at 21 nmol/L

Based on what I've read it seems like my corrected calcium may be closer to the normal range than high-normal, I'm also dealing with a lot of anxiety over what this could all mean, so I just want to know how worried I need to be over this. Worth noting my doctor seems to think my physical symptoms are related to anxiety, which we're working on now.

Why does primary hyperparathyroidism have high Ca2+ in urine vs. Familial hypocalciuric hypercalcemia has low Ca2+ in the urine? Thx :)

I'm in the process of being diagnosed with hEDS or HSD. One of my most confusing and consistent blood test results has been high calcium in the blood, but with low parathyroid hormone/hypoparathyroidism. I've had the 24-hour urine test from an endo, and my PCP tells me every time with the calcium that I'm probably dehydrated (despite the fact that I gorge on water for a couple days before blood draws so that the blood will flow easily). Just want to make sure they're not missing anything that could be related to the increased risk for osteopenia/osteoporosis in hEDS. I'm not the most active person, but I do work with kids at a preschool, so I'm not sedentary. I'm 25F.

(Bonus points if anyone knows anything about hEDS related to consistently mildly elevated blood potassium/hyperkalemia... that also gets blamed on dehydration each time.)

Hello there, I've never really watched a full season of the show, but man do you gotta love house's sense of humor(sometimes).

I was hoping someone would be able to site any episodes they know of mentioning the conditions "Hypercalcemia" "Hyperparathyroidism", and "MEN1"(or wermers syndrome).

Reason being is that my mom and I love the show to some extent or another, and both of us actually have Hypercalcemia, from MEN1.

Any response is appreciated, and if you've got any questions for someone with a 1/30000, feel free to ask.

EDIT: I am aware that Grey's Anatomy mentions Wermer's syndrome but it's just in passing and doesn't really have much to do with bones groans &/or psychic overtones.

hiiii 26/f wondering how hard i should push to just get my parathyroids looked at (surgery). i’ve been mostly bedridden and very, very ill my whole life, and i have some answers but it’s clear we’re missing some big pieces and i’m tired of (not) living this way but also don’t want to go under the knife recklessly since i’m high risk so i’m wondering if there’s anyone else like me

• hypercalcemia for at least 8 years, it’s not always there but it keeps popping up especially during er trips or times i feel worse
• other persistent electrolyte imbalances (hypokalemia most often)
• arrhythmia from all that
• pth 21. somehow all these years it’s only been tested once
• long term vitamin d deficiency in spite of high supplementation
• lots of chronic illnesses, very symptomatic and have spent most of my life housebound and mostly bedridden and chronically malnourished (eds, pots, mcas, cci, gastroparesis, fibromyalgia, pcos, hemiplegic migraines, like 4 other types of migraines, osteoarthritis, mystery seizures, mystery vestibular issues, outrageous motion and light sensitivity, plenty of other stuff)
• i broke a bone when i absolutely should not have based on the fall but haven’t gotten a bone scan. the bone took a solid year+ to heal
• i get waves of worse symptoms in episodes? this is probably the worst part. involves clonus, confusion/disorientation, nausea, dizziness, high bp, feeling faint/actually painting, lots of bathroom trips, weakness so bad i can’t walk or pick up cups to drink, tachycardia, shaking/twitching, babbling instead of speaking or unable to speak at all, often this correlates with hypercalcemia and hypokalemia since the severity of tachycardia + neuro symptoms usually lead me to the er
• doctors keep circling back to addisons + thyroid but finding nothing. extensive family history w thyroid nodules goiter hashimotos tumors etc, but no parathyroid.
• everything has gotten worse the older i get

i’ve spent hours trying to learn about this after my doctor started looking into it, found parathyroid.com and saw their huge article about having hpt without having high pth which piqued my interest considering my symptoms and levels. i would just immediately start the consult process with them since they’re the experts but i am too sick to travel, i typically can’t even get to my doctors office ~10 minutes from my house.

so, would i be bonkers for pursuing this more adamantly? if i do pursue it is an endocrinologist the best choice? doe

Hello I am a 25 year old male with no known health issues. Weight at about 155 and height 5'7 .So I had some blood work about 6 months ago that showed on a normal metabolic assay everything within normal ranges except an albumin level of 5.3 which was .2 higher than the upper reference range of 5.1. As well as a serum calcium level of 10.5 which was .2 higher than the upper reference range of 10.3. Everything else on the bloodwork was normal. My doctor said she wasnt worried about this and that maybe I was dehydrated on draw day as well as showed me the formula to correct calcium for albumin levels. I had blood work repeated for this test yesterday and got my results back that everything was normal again except a calcium level of 10.6 .3 higher than the upper reference range and my albumin level had gone back within the range but was still 5 .1 less than the maximum range. I am the type of person to have anxiety over this stuff. I have read online to correct calcium and some places say to not correct calcium but that the real only cause of high calcium is either hyperparathyroidism or cancer. Im looking for guidance on this as I probably cant get in to see my doctor until tuesday or wednesday and am suffering from anxiety! Any input would be appreciated.

Title basically says its. Came across this bit of info in FA and trying to figure out why it's the case. Any ideas?

23M USA

I Have Hypercalcemia of 11 MG per DL. My parathyroid and thyroid panel are normal.

I may or may not be experiencing symptoms due of Hypercalcemia.

I have severe muscle twitching all over my body. Sharp Abdominal pain, neurological problems, and weight loss(i have lost 7 pounds in the last year without trying.)

Do you personally think this Is this worth investigating further with my doctors?

He’s a 3 year old male altered cat. No prior medical history.

He’s been depressed & lethargic lately. Hides under the bed in the guest room for about 2 weeks. He’s still eating, drinking, voiding & having BMs. He still loves pets & purrs. He still has life & color in his eyes. Labs showed hypercalcemia. We started him on lactulose because at the time he was in a different room & was not using the cat box, but he’s had several BMs since then. He seems like he feels a bit better now since he’s not so constipated. I’m waiting to hear back from my vet on what to do moving forward. But I work nights, it’s 4am & currently my mind is racing so I had the bad idea to turn to the internet.

But what can I expect? I’m assuming more elaborate bloodwork to assess for parathyroid/cancer panels. If it’s idiopathic is that an acute or chronic thing? I know in humans we’d start an IV with normal saline & start a medication regimen. Is it a similar treatment plan?

Background: 5'8 106 lbs, 43, female, Crohn's disease post total proctocolectomy with end ileostomy and disease currently located in stomach, gastroparesis with j tube, hydration issues

Meds: humira, reglan, pantaloc, nortriptyline, zopiclone, tylenol, gravol, simethicone

For the last few years my calcium level has been high (2.66 in Canada, 10.6 I think in the states). My GP was convinced I had hyperparathyroidism (and I have symptoms of it) but my PTH came back normal.

I'm obviously don't have end stage cancer and my calcium intake is not excessive so I'm stumped. The only thing my GP, dietitian and I think it could be is dehydration. I'm constantly dehydrated which I know pushes my electrolytes up so possibly it's pushing my calcium up?

49F, USA, subacute worsening things including weird mottling of skin, rashes, red and swollen fingers, easy unexplained bruising in odd places, severe headaches, fatigue, just feeling very "sluggish" and ill - hard to describe. Abnormal labs and 24 hour urine with nephrology workup.

Really could use some help please. If you ran blood labs and a 24-hour urine test, and results included low glucose (41), persistent hypercalcemia (11.2 - going up w/3 lab tests so far), and low creatinine clearance (70) - what kinds of things would be in your differential? (FYI seeing nephrology doc tomorrow, I just really hope for at least a vague idea of some possibilities or thoughts and if I'll possibly be facing more testing before going in).

Other:

• I do NOT have diabetes, high blood pressure, or high cholesterol.
• I DO have seropositive overlapping MCTD, pulmonary hypertension secondary to that, and flares of inflammatory pulmonary fibrosis for several years.
• Not currently on any meds (used to take Remicade, Arava - stuff for the CTD, but no longer bc they haven't helped in a long time). I haven't taken OTC meds in awhile bc they don't help with my symptoms.
• Never-smoker, don't drink alcohol (not even "socially")

What could be wrong? TIA!

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