Is there a risk here for developing an autoimmune disorder where we teach our bodies to target molecules that fit our ACE2 receptors (the key molecules, not the receptors, angiotensin, I think it's called) and inadvertently, this creates some cascade which leads to a cycle of really high blood pressure/ immune system inflammation? Are the coronavirus spikes different enough from our innate enzymes that this risk is really low?
Edit: I added the bit in parentheses, as some ppl thought that I was talking about the receptors themselves, my bad.
Another edit: This is partially coming from a place of already having an autoimmune disorder, I've seen my own body attack cells it isn't supposed to attack. With the talk of expedited trials, I can't help but be a little worried about outcomes that aren't immediately obvious.
Hey guys has any one made a low carb beer? If so did you use enzymes? How did it turn out?
I’ve been considering using these Alpha Galactosidase Tablets .
I’ve also seen a recipe where someone put Beta Amylase in the secondary to do the same thing.
Thanks for any help, 🍺
Hello, I just had this thought not too long ago. Since our bodies are essentially "organic laboratories," could we hypothetically take certain substances before dosing Safrole (Used to make MDA and MDMA) so that it's converted into something else? Perhaps MDA or another psychoactive drug?
I've read of this being done with other drugs, like grapefruit juice being used to make MDMA safer by preventing some of it from metabolizing into MDA.
I read that Piperine taken alongside DXM metabolizes it into a different drug as well, although I forget which. If someones interested i'll dig up the post.
Is it possible that this could be done with safrole though? It seems like it could to me, hoping someone with a more nuanced understanding of this can fill in.
Some helpful links:
Oh, and for anyone worried about safroles potential toxicity and carcinogenic effects, read this article. It sort of tore apart the notion that safrole is carcinogenic in humans, there is evidence suggesting moderate doses are anticarcinogenic.
I decided to use test prop for trt after hearing good things about it for estrogen sensitive people and the day after injection I woke up feeling horrible. Nauseous, blurry vision, stomach pain, constipation, fatigue, muscle weakness. I went to urgent care and turns out my liver enzymes were through the roof! I don’t drink or do any other drugs so it was 100% the test prop. Also my rbc was really high as well. Anyone ever experience this type of systemic inflammation from test prop before? I’ll definitely be going back to test E
If so, is there any literature that addresses how much/how long?
Today Enzyme has officially gone live!
This means anyone can open and manage an asset management fund in a secure and transparent way. Create your portfolio, manage assets, collect fees! Integration with lending protocols like Compound, AMM like Uniswap, all Synthetix assets and more.
Learn more about the release here.
I wanted to make an exfoliating kind of scalp serum but now with any salicylic acid or BHA/AHA or anything. I've had some of the papaya mango enzymes from formulator sample shop and thought maybe they'd be a good fit for this? I think I expected to feel something a bit more but it's pretty mild. I feel like it's helped a bit with my itchy scalp too but that could all be in my head. I'm thinking maybe in the future I'll add some willow bark extract or some bromelain powder. There's no fragrance in this either, it's colored with a tiny tiny amount of water soluble dye.
Ingredients: (30g total)
89.5% water (26.85g)
3% glycerin (0.89g)
5% pap ango enzymes (1.5g)
0.5% liquid germall plus (0.15g)
You can't hear an enzyme.
Hi everyone, I’ve just had a phone call from my doctors surgery in relation to elevated liver enzymes. At the time I never thought anything of it so I googled finasteride effects on the liver and elevated liver enzymes can be caused due to the drug. Should I call them back and tell them that I take finasteride as they have me booked in again to test for coeliac disease in which elevated liver enzymes is one of the signs of the disease.
Has anyone taken DAO supplements without the capsule? I want to take Histamine Block (Seeking health’s DAO) and I think I’m reacting to the capsule. Does it work for anyone without the capsule?
I’m also about to try NaturDAO, and I’d like to eliminate the capsule if it works the same.
I’m also wondering what digestive enzymes do you use? And how much do you take? To digest starches and fibre for example. Also how do you take it with meals? Do you take betaine HCL and what dose?
Thanks a lot in advance (good luck everyone!)
Title pretty much says it all. Been on Testosterone since September now. Know I’ve made a few posts in the past but thankfully all my issues have been resolved with time and sticking with it.
However, I went in to get follow up labs and my liver enzymes came back pretty elevated. Alt I believe was in the 100s. It’s pretty concerning since my last labs in October showed elevated liver enzymes too. They’ve improved since then but they are still elevated. Everything else came back great which was good. But this liver issue is not good
It’s weird because I’m at a Loss. I have no symptoms and feel great. I don’t drink that much at all.
Anyone else have seen this? I’m wondering if the testosterone is to blame
Really interesting read on how phenylbutyrate (PBA) looks to be a way of improving treatment when combined with lower doses of acyclovir to remove herpes from cells.
Even better - the fact it is already FDA approved means it's likely to appear on the market more immediately.
Shukla said. "The added bonus of this drug already being approved by the FDA to treat a rare enzyme disorder means that we may be able to quickly develop a marketable new combination therapy in the near future."
" When they tested a combination of PBA with acyclovir cells infected with HSV-1, the drug combo was able to completely clear the virus from the cells faster and better than either drug alone*. "*
I know there's huge progress on vaccines/gene therapy but looks like there's good news in the mean time in providing more effective treatment options too - every day it's getting better and better gang! :)
Is it safe? And do you always have to take it with food? Or can it help with symptoms as well? Thanks
Hi everyone... I know you aren't doctors, and I'm not looking for false hope, but I'm really scared, and could use some personal anecdotes or reassurance.
I had some less-than-ideal blood test results just before Christmas: elevated MCV and MCH. My doctor called to explain that this meant my blood cells are "big", which can be a sign of chronic alcoholism.
This was a "wake up" call for me. I did drink over the holidays, but far less than I normally would (my "usual" is a bottle or two of wine a day), and I haven't touched a drop since January 1.
She sent me for a follow up to look at GGT and ALT (among other things). Got blood drawn today (after one week no alcohol), and got results this afternoon: GGT is 100 (normal range 12-37), and ALT is 61 (normal range <36). (I haven't heard directly from doctor yet, but was able to see the results by logging into my lab's virtual dashboard.)
I had mentally prepared myself to see these enzymes elevated—I had these numbers drawn in 2018 and they were slightly up but still within normal range—but seeing them 3X and 2X the normal range respectively has scared the ever-living fuck out of me.
Anyway, I am here to try to orient myself a little, and attempt to calm my nerves before going into the weekend, as I likely won't hear from doctor until Monday at the absolute earliest. Google is telling me anything outside normal range is Bad with a capital B. But I'm seeing some folks in this sub with ranges waaaaay higher than I have, whose enzymes returned to fully normal after being sober for several months or a year.
I'm just looking for perspective... I have no way to contextualize whether a number like GGT of 100 is like, scary and advanced cirrhosis time, or whether it's more like a "bad but not horrifying" warning sign. What's "normal" in the world of "elevated"?
Any input, experience, or words of encouragement would be so appreciated!
For what it's worth, I'm 30, female. I've been drinking heavily since I was 20, but for many years it was just on weekends: binge drinking with friends, often blacking out. Since COVID though, I've kind of spiraled into drinking 750mL to 1L of white wine per day, sometimes more. I haven't had a drink in a week, and haven't felt this good in months, if not years. IWNDWTY!
Today we’re going to be focusing specifically on the pain relief properties of kavalactones. Ibuprofen, naproxen (Aleve), and aspirin are common drugs which fall into the class called “NSAIDs”. Non-steroidal anti-inflammatory drugs share a common quality. They inhibit the activity of one, the other, or both cyclooxygenase enzymes known as COX-1, and COX-2. Cyclooxygenase is an enzyme that is responsible for forming prostanoids that play a major role in pain and inflammation . Most NSAIDs work by non-selectively blocking both COX-1 and COX-2 enzymes, thus reducing inflammation and pain. Kava was shown to inhibit both COX-1 and COX-2 enzymes substantially with all kavalactones. In fact, kava was shown to inhibit COX-1 enzymes by a greater or equal degree across all kavalactones in comparison to Ibuprofen, naproxen, and aspirin. Dihydromethysticin and yangonin were shown to be as good as the three pain relievers mentioned in regards to COX-2 inhibition , similar to drugs like Celebrex. If you’re noticing relief from aches and pains after drinking, or maybe seeing relief from arthritis this could lend evidence towards why.
 Cyclooxygenase. (2020, December 02). Retrieved from https://en.wikipedia.org/wiki/Cyclooxygenase
 Wu D, Yu L, Nair MG, DeWitt DL, Ramsewak RS. Cyclooxygenase enzyme inhibitory compounds with antioxidant activities from Piper methysticum (kava kava) roots. Phytomedicine. 2002 Jan;9(1):41-7. doi: 10.1078/0944-7113-00068. PMID: 11924763.
I've recently found digestiev enzymes seem to help my LPR, more than PPIs or any antiacids do at least. My throat soreness isn't gone but it seems to be much more manageable on them. Now my question is just if anyone has knowledge or experience regarding the matter. Are there any negative consequences with taking them long term?
I’ve been taking NOW Digestive Enzymes for about 2 months and they have really helped me combat my chronic diarrhea. My question can I take these long term? I’ve heard mumbling about how if you take them your body will stop making them on it’s own, but I have no clue if that true or not.
I have a UV light and can see the yellow pee stains, but they’re still yellow after using an enzyme cleaner. I read that they’re supposed to turn blue or white; is this not always the case?
ALT 86 ALKALINE PHOSPHATASE 129 U/L AST 40 GGT 311
So, I've already been eating carnivore for the last year. Exercise lightly 3 days a week. Don't drink often. I have no viral infections. No results for inflammation or for autoimmune. Is there any reason I may be missing?
Sooo I usually never forget my enzymes when I eat to take my Trikafta. But last night was the first time. I had a Ensure shake so not the worst thing in the world...
But here’s the kicker, I didn’t realize I forgot them until I saw them on the counter this morning and I have no stomach ache or anything.
Has anybody need less or stopped taking them once on Trikafta?
Thanks me and happy new year!
A few months ago there was a collaboration announced between Enzyme and Synthetix.
Today Enzyme has officially gone live!
This means anyone can open and manage an asset management fund in a secure and transparent way.
Included on the list of tradable assets is all Synthetix assets!
Learn more about the release here.