Chemistry newb question, so please excuse any basic errors. What would be the simplest way to recover (separate / extract) Polyethylene Glycol (PEG 1450) from water? Passing it thru the right size micron filter, perhaps? Changing the ph of the solution?
Hi all. My mom had an allergic reaction this summer to a cortisone shot that had her hospitalized. She couldn't figure out what was in the injection that caused this, but today she found out it's polyethylene glycol.
She spoke with her allergist and he said it was important to test out all of these potential allergies because it might affect her eligibility for the COVID Vaccine. Turns out she is allergic to polyethylene glycol.
What would her options be for this situation? She has expressed fear that she will not be able to get any of the COVID vaccines that are available.
Searching Google, it seems like they're different.
However on Amazon, 99% of the listings that look legit, refer to it as Propylene Glycol. I don't want to buy this and it be the wrong thing. Can someone fill me in? Thanks all!
FDA suggests polyethylene glycol (PEG) may be causing the allergic reactions to COVID-19 vaccines
'The U.S. Food and Drug Administration is investigating around five allergic reactions that happened after people were administered Pfizer Inc and BioNTech SE’s COVID-19 vaccine in the United States this week, a top FDA official said late on Friday. Dr. Peter Marks, director of the FDA’s Center for Biologics Evaluation and Research, said at a press conference that the allergic reactions had been reported in more than one state, including in Alaska. Marks also said that a chemical called polyethylene glycol (PEG) that is an ingredient in the Pfizer vaccine - as well as the Moderna Inc vaccine authorized on Friday - “could be the culprit” causing the reactions. Marks said that allergic reactions to PEG could be somewhat more common than previously understood.' https://www.reuters.com/article/us-health-coronavirus-vaccines-fda/fda-investigating-five-allergic-reactions-after-pfizer-shot-in-u-s-idUSK
Article from Children's Health Defense (a non-profit organization): https://childrenshealthdefense.org/defender/pfizer-covid-vaccine-reaction-fda-peg/
The article contains a pretty long list of drugs containing PEG
This is more like something I would ask a pharmacist but I'll try in this subreddit since I don't know a subreddit when I can ask pharmacists specifically.
I(18F) take vyvanse for my ADHD. I haven't had a bowel movement for 3 days and I forgot to take a laxative yesterday night so now I want to take it in the morning but I also took vyvanse an hour ago. The laxative is polyethylene glycol 3350 and I wonder if I can take it even if I took vyvanse this morning? Would there be any bad drug interaction?? I've searched interactions with vyvanse and it says the effect can be moderate. I really want to take it this morning so is it safe to do so?
Weird question, if you were to get a 1 m^2 carbon fibre panel and a 1 m^2 of PETG clear sheet which one would be heavier? Assuming they'd have the same thickness.
33 year old Male
Saw something about Colace? (Docusate Sodium & Sennocides). Would really prefer it to be a powder. Thank you!!!
I take 20g fiber from Benefiber daily. As a result, I need to soften my stools since otherwise it is dry.
Is there a difference between Polyethylene Glycol and Docusate Sodium in which would be better? Polyethylene Glycol seems to upset my stomach more than Docusate Sodium.
I am prescribed alprazolam. I know taking it orally produces two less potent metabolites (less potent than alprazolam before it went through first-pass metabolism), the alpha-hydroxy-alprazolam metabolite, which is half as potent as alprazolam alone while the benzophenone metabolite is inactive.
I want to avoid these metabolites and only have alprazolam in my system but I refuse to inject anything not made to be injected (aka by nurses in a hospital when I need it). And I know from many studies, as well as the existence of the Macy Catheter (for rectal administration of drugs), that properly administered and made rectal solution is as effective as a slow IV drip for at least some if not many drugs...right?
I know alprazolam is soluble in polyethylene glycol and alcohol. Alcohol burns the rectum. So I mix polyethylene glycol 3500 (miralax) in water. I use a 1 mL oral syringe and pour 1 mL of miralax-laced water on the pill in this little container until it dissolves entirely in 30-90 seconds and then I suction it back into the 1 mL oral syringe and plug it just a few centimeters at most into my booty, as to avoid first-pass metabolism in the rich blood supply present that bypasses first-pass metabolism; this is in the anal column, I believe?
Are my methods, administration, and reasonings based in rationale and logic? Does it make sense to administer it the way I have described?
I have googled and pubmed’d this and found little to nothing helpful, not even on forums or here on reddit.
So am I a fool or do have some idea of what I’m doing? Please be kind but honest.
I have a question: Is it possible to create a "shell" of polyethylene glycol (ideally spherical) with a liquid "core" and if so, how would it be possible to manufacture such a thing?
Thank you and best regards
Just would like to get some feedback related to title on what the community knows about these substances and how they feel about these substances.
Please if you have an opposing idea or feeling different then someone else may possibly post don't start an argument. That being said nothing wrong with disagreeing civilly and preferably with linked scientific evidence.
Given some responses may be anecdotal they are still desired as it is the accumulation of anecdotal evidence that can lead the way to the truth.
Existing pharmaceutical recipes seem too conservative in their approach.
Research from 25 years ago studied alternatives like PEG or polyvinylpyrrolidone
Pros: It may allow for higher concentrations of estradiol, allowing to use just a few drops with faster absorption: "Generally, both the uptake and flux of OE through both human skin and silastic membrane increased with increasing degree of saturation. Stratum corneum showed an 18.8 ± 4.88 times increase in uptake from a supersaturated solution of 18 times saturation"
Cons: 18x the doses may have negative side effects. The lack of existing pharmaceutical research means we would be guinea pigs
(21, Female, 5'8, 150lbs, no medications) I've been chronically and severely constipated for the past 4-6 months. I'm still working with specialists to figure out what's wrong, but my neurologist suspects MS right now because of vision problems and nerve pain. I also have endometriosis, but my gynecologist says that it's not bad enough to cause constipation this severe... I go once or twice a week if I'm lucky, and I'll frequently get so backed up that I puke until I'm able to go to the bathroom. It's basically just a big mess of symptoms and specialists right now, but my gastroenterologist has been trying to help me deal with the constipation in the meantime, telling me to take fiber and Restoralax daily up to twice a day. My question is, is Restoralax safe for regular and long-term use? My doctor says it's okay but I know that laxatives can make your system dependent on them so I don't want to make things worse, and I don't know if the cause of the constipation makes any difference to what treatment should be taken. That being said, I can't really go to the bathroom without them :( it feels like the stool just gets stuck every single time or sits there and it's really, really uncomfortable. should I seek a second opinion from another doctor or just keep taking the laxative until I get my brain MRI?
PEG is a very common excipient in pharmaceutical products. The literature indicates that allergic hypersensitivity reactions to higher molecular weight PEG (aka Miralax, PEG 3350) are not unheard of. There do not seem to be any reported cases of hypersensitivity to lower molecular weights (i.e. PEG 400).
Many common medications list PEG as an inactive ingredient but leave an unspecified molecular weight. Would there be any way to tell what version of PEG is used in these products (such as famotidine, fexofenadine, ibuprofen)? Thanks
Urea is highly polar but why does it disrupt hydrophobic interactions? Wouldn't urea hydrogen bond with other water molecules, leaving cellulose -OH groups alone?
Thanks for any response!