Low-carbohydrate diets and the risk of pancreatic cancer: a large prospective cohort study
Published: 22 January 2021 Article history Cite Permissions Share Abstract Low-carbohydrate diets have become a popular approach for weight loss in recent years. However, whether low-carbohydrate diets are associated with the risk of pancreatic cancer remains to be elucidated. Hence, we examined the association of low-carbohydrate diets with the risk of pancreatic cancer in a US population. A population-based cohort of 95962 individuals was identified. A low-carbohydrate-diet score was calculated to quantify adherence to this dietary pattern, with higher scores indicating greater adherence. Cox regression was used to calculate risk estimate for the association of the low-carbohydrate-diet score with the risk of pancreatic cancer. Subgroup analysis was used to identify the potential effect modifiers. After an average follow-up of 8.87 years (875856.9 person-years), we documented a total of 351 pancreatic cancer cases. In the fully adjusted model, the highest vs. the lowest quartiles of the overall low-carbohydrate-diet score was found to be associated with a reduced risk of pancreatic cancer (hazard ratioquartile 4 vs. 1: 0.61; 95% confidence interval: 0.45, 0.82; Ptrend<0.001). Subgroup analysis found that the inverse association of low-carbohydrate diets with the risk of pancreatic cancer was more pronounced in individuals aged ≥65 years than in those aged <65 years (Pinteraction=0.015). Similar results were obtained for animal and vegetable low-carbohydrate-diet scores. In conclusion, low-carbohydrate diets, regardless of the type of protein and fat, are associated with a lower risk of pancreatic cancer in the US population, suggesting that adherence to low-carbohydrate-diets may be beneficial for pancreatic cancer prevention. Future studies should validate our findings in other populations.
Low-carbohydrate diets, pancreatic cancer, primary prevention, prospective study
Issue Section: Original Article
I'm very afraid of Pancreatic cancer... If They found that I have this cancer , Im not gonna do the chemotherapy , Im gonna accept my death.
I am celebrating his life, being his friend, and being my "normal" self - but privately I have been getting hit by walls of sadness - lately I have been compulsively exercising as a way to cope (and not drink alcohol which is my unhealthy coping mechanism). I'm also trying not to shove down my grief either...I'm trying to befriend my grief - nourish and support it - give it safety and love and space to feel..but it's a tricky balance - because I don't want to grieve for my friend when he is alive - but privately it is happening randomly - it just hits me - normally I go for a run and that helps. I'm trying to figure out how not to repress my sadness and accept grief as a part of life...
We are just in shock.
My (32F) husband will be 37 in March and we were just told today that he will need to start chemo next week.
The dr said that this is becoming more common in younger people and they don’t know why. It’s just genetic I guess.
Oh and we need to start looking for a sperm bank ASAP. We have a 2 year old and we wanted more kids. So now there’s a whole world of that.
And the calls from nurses and doctors keep coming in as we figure out appointments. I don’t know who is who and where we need to be when. I promised my husband that I would figure it out and be like the chief of staff so all he has to do is show up and do the things. But it’s hard already and we are now 8 hours in.
But it is cancer. Possibly small intestines cancer that has moved to the pancreas but, because it’s mostly in the pancreas, we are treating it like pancreatic cancer because the treatment is the same either way. Next step is a celiac plexus to block the pain on Thursday. He hasn’t slept in weeks and the pain is so bad. I ran out to get CBD oil in the freezing icy snow in an act of desperation and it helped him mellow out a little. Any advice with that? That’s a whole new world too.
Then next step is a port to prep for chemo. The cancer is wrapped around an essential artery (SMA) and needs to unwrap a little before surgery. Possibly radiation in between but not necessarily.
Dr says the most important tool in the toolbox is the mind. The ones who do worse are the ones who hide under the covers and give up.
As far as chemo, it's not the worst kind. If it's a car, he says the kind with losing hair and in toilet is like a Ferrari and the kind you don't feel is like a smart car and we are doing the mustang version.
I’m just spilling out all the words because I don’t know what else to do. Advice for our first night with this news?
Curious if anyone has any recommendations when chemo stops working. For the longest time there was no new growth, and now there is.
Looking into healing foods (ginger, pear), but curious about what other gambits one might consider.
They will be discussing the results of the Phase 2/3 Study of SM-88 in patients with Metastatic Pancreatic Cancer on January 17th, 2020.
SM-88 is an oral, investigational cancer metabolism-based therapy that has demonstrated clinical responses across 15 different cancers
New oral approach aimed at disrupting cancer metabolism in metastatic pancreatic cancer; ~ 58,000 cases annually in U.S. alone
In clinical trials to date, SM-88 demonstrated a favorable safety profile
SM-88 is being evaluated in multiple late-stage clinical trials as a potential treatment for patients with advanced pancreatic cancer
About Tyme Technologies: Tyme Technologies, Inc., is an emerging biotechnology company developing cancer therapeutics that are intended to be broadly effective across tumor types and have low toxicity profiles. Unlike targeted therapies that attempt to regulate specific mutations within cancer, the Company’s therapeutic approach is designed to take advantage of a cancer cell’s innate metabolic weaknesses to compromise its defenses, leading to cell death through oxidative stress and exposure to the body’s natural immune system. With the development of TYME-18 and TYME-19, the Company believes that it is also emerging as a leader in the development of bile acids as potential therapies for cancer and COVID-19.
A week or so ago, my uncle went to the hospital for a severe stomach ache and a fast heart rate, last Monday, they found cancerous cells in his liver and bones. Unfortunately, it's gotten worse, they've found it started in his pancreas and travelled to his bones, hip, liver, and even his testicles. Obviously, it was listed as terminal, he has one year left, 6 months of chemo ahead of him. This Monday, he came home from the hospital, but just three days later, he's back because his bones are so fragile and could possibly shatter. What I'm asking is how long could he bear with it? Based on any similar experiences, what might happen in the next 12 months?
Hello, my dad was diagnosed with pancreatic cancer and he had operations, I believe not Whipple, to remove the tumor (6cm) at the pancreas tail and spleen last August. Unfortunately he was very weak and it was decided chemo was not suitable for him. He had jaundice last November and has been weakened by the cancer very quickly. It was found the cancer had spread to his liver. He's developed a fever for the last 3 weeks that doctor has to admit antibiotics without any success. I'm worried about sepsis if the antibiotics fail to work. Any had similar experiences?
In recent study published on Nature Medicine, Bockorny et al. 1 performed a single-arm phase IIa trial (COMBAT study, NCT02826486) to evaluate safety, efficacy, immunobiological changes, and potential biomarkers for the CXCR4 inhibitor BL-8040, combined with a PD-1 antagonist (pembrolizumab) as a second-line or third-line treatment for patients with metastatic PDAC. This evidence translates the theory of reprogramming tumor immunosuppressive microenvironment into clinical practice and supports that targeting chemokines/chemokine receptors facilitates the immunotherapy of pancreatic ductal adenocarcinoma (Fig. 1 ).
Recently, we found that combinations with CCL5/CCR5 antagonist and the anti-PD-L1 antibody inhibited tumor growth and improved overall survival in mice models of PDAC.5 Here, we first determined that cancer-FOXP3 mediated immune escape by recruiting regulatory T cells via upregulation of CCL5. We provided the rationale that cancer-FOXP3 could identify PDAC patients suited for combination of ICI and the chemokines/chemokine receptors inhibitor, in order to improve response. Interestingly, CCR5 and CXCR4 serve as the co-receptors for HIV-1 entry into T cells, and they have been used as popular targets for the development of new drugs. BL-8040, the peptide-based motixafortide, exhibits encouraging results in combination treatment. Meanwhile, the CCR5 antagonists, such as the small molecular reagents like maraviroc and the humanized monoclonal anti-CCR5 antibody leronlimab, have achieved the primary endpoints in phase 3 clinical studies on HIV, and therefore could be considered for therapeutic repurposing in PDAC. https://www.nature.com/articles/s41392-020-00267-8
2 weeks ago we celebrated dad's 70th with the immediate family. Everything seemed fine and normal.
A week later we celebrated nieces birthday outside at a park. We found out that mom has been feeling nauseous and hasn't been eating and has been week for the past month.. once we found out all the kids nagged her until she finally agreed to get checked out. This was on Saturday.
She went to the emergency room (to get tests done quicker, her next available doctors appointment was like a month from now) and they hospitalized her. Yesterday they told us she's dying.
Everything turned upside down in a moment. Me and my siblings are in total shock. Dad is trying to be strong but we can tell he's terrified. We don't know how he'll hold up without her.
I don't really know how to process this. Every moment my mind is not distracted I break down sobbing. I feel cheated. She's only 67. My sister is pregnant and we don't know if she'll even make it till her grandson is born.
In addition due to Covid we have not seen her as much as we would've this past year. We were robbed of what is possibly her last year.
I guess I'm just venting. I don't know what to do. I don't know how to continue from here.
Anyone who has handled this situation, any advice would be appreciated
Edit: I am too emotional to answer you guys individually but I'd like to thank everyone who commented.
Just reading your stories makes me feel less alone, more normal, don't know how to describe it.
I appreciate you all.